United States securities and exchange commission logo July 13, 2022 Joern Aldag Chief Executive Officer HOOKIPA Pharma Inc. 350 Fifth Avenue, 72nd Floor, Suite 7240 New York, NY 10118 Re: HOOKIPA Pharma Inc. Registration Statement on Form S-3 Filed July 11, 2022 File No. 333-266084 Dear Mr. Aldag: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jason Drory at 202-551-8342 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Seo Salimi, Esq.