|
Time
|
| | 09:00 a.m., Eastern Time | |
|
Date
|
| | Tuesday, June 1, 2021 | |
|
Place
|
| | Online at www.virtualshareholdermeeting.com/HOOK2021 | |
|
Purpose
|
| |
To elect Jean-Charles Soria and Michael A. Kelly as Class II members of the Board of Directors, to serve until the Company’s 2024 Annual Meeting of Stockholders and until their successors are duly elected and qualified;
To ratify the selection of PwC Wirtschaftsprüfung GmbH as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2021; and
To transact any other business that may properly come before the meeting or any adjournment thereof.
|
|
|
Record Date
|
| | The Board of Directors has fixed the close of business on April 1, 2021 as the record date for determining stockholders entitled to notice of and to vote at the meeting. | |
|
Meeting Admission
|
| | All stockholders as of the record date, or their duly appointed proxies, may attend the meeting. In order to be able to attend the meeting, you will need the 16-digit control number, which is located on your Notice, on your proxy card, or in the instructions accompanying your proxy materials. Instructions on how to participate in the Annual Meeting are also posted online at www.proxyvote.com. | |
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Voting by Proxy
|
| | If you are a stockholder of record, please vote via the Internet or, for shares held in street name, please submit the voting instruction form you receive from your broker or nominee, as soon as possible so your shares can be voted at the meeting. You may submit your voting instruction form by mail. If you are a stockholder of record, you may also vote by telephone or by submitting a proxy card by mail. If your shares are held in street name, you will receive instructions from your broker or other nominee explaining how to vote your shares, and you may also have the choice of instructing the record holder as to the voting of your shares over the Internet or by telephone. Follow the instructions on the voting instruction form you received from your broker or nominee. | |
CLASS I DIRECTOR NOMINEES – For a Three-Year Term
Expiring at the 2023 Annual Meeting of Stockholders |
| |
AGE
|
| |
DIRECTOR SINCE
|
|
Joern Aldag has served as our Chief Executive Officer since June 2016 and as a member of our board of directors since June 2018. Mr. Aldag served as the Chief Executive Officer at uniQure N.V. (Nasdaq: QURE, formerly, Amsterdam Molecular Therapeutics N.V.), or uniQure, from October 2009 to December 2015 and as an advisor to the board from January 2016 to May 2016. Prior to his tenure at uniQure, Mr. Aldag was President and Chief Executive Officer of Evotec AG from November 1997 to December 2008. Mr. Aldag serves as a non-executive director on the board of Idorsia Pharmaceuticals Ltd. and Chairman at GeneSpire Srl. Mr. Aldag also served as a non-executive director on the board of Unum Therapeutics, Boston, USA from 2016 to 2020, and as the Chairman of Molecular Partners AG, Zurich, Switzerland (SWIX: MOLN) from 2007 to 2018. He co-founded G7 Therapeutics AG in 2014, which was acquired by Heptares Therapeutics Ltd. in 2016. Mr. Aldag received business degrees from the Harvard Business School (Advanced Management Program) in 1994 and from the European Business School (Diplom Betriebswirt) in 1982. Our Board of Directors believes that Mr. Aldag’s experience gained from serving as our Chief Executive Officer, combined with his previous qualifications and the skills and experience he has developed during his extensive career in the life sciences industry, qualify him to serve as a member of our board of directors. | | |
62
|
| |
2017
|
|
Jan van de Winkel, Ph.D., has served as Chairman of our Board of Directors since October 2017. Dr. van de Winkel is a co-founder of Genmab A/S and has served as the company’s President and Chief Executive Officer since June 2010. He has also served as a Professor of Immunology at Utrecht University since 1996. Prior to June 2010, he served as Genmab’s President Research & Development and Chief Scientific Officer. Dr. van de Winkel serves on the board of directors of LEO Pharma and Omega Alpha SPAC. Our Board of Directors believes that Dr. van de Winkel’s experience in biopharmaceutical research and development and his experience in managerial and director roles in life sciences companies qualify him to serve on our Board of Directors. | | |
60
|
| |
2017
|
|
David R. Kaufman, M.D., Ph.D., has served as a member of our Board of Directors since April 2019. Dr. Kaufman is currently the Chief Medical Officer of The Bill & Melinda Gates Medical Research Institute, where he has served since January 2018. Dr. Kaufman previously held several positions at Merck Research Laboratories from June 2011 to December 2017, including Head of Translational Oncology from 2017 to 2018, Executive Director, Clinical Oncology from 2015 to 2017 and Associate Director, Merck Drug Development and Leadership Program from 2011 to 2014. Dr. Kaufman serves a member of the board of directors of the Society for Immunotherapy | | |
48
|
| |
2019
|
|
CLASS I DIRECTOR NOMINEES – For a Three-Year Term
Expiring at the 2023 Annual Meeting of Stockholders |
| |
AGE
|
| |
DIRECTOR SINCE
|
|
of Cancer. Dr. Kaufman received a Ph.D. in molecular virology/immunology from The Rockefeller University and an M.D. from Weill Medical College of Cornell University. Our Board of Directors believes that Dr. Kaufman’s extensive background in pharmaceutical research and development and his experience in managerial and executive roles qualify him to serve on our Board of Directors. | | | | | | | |
CLASS II DIRECTORS – TERM EXPIRING AT THE 2021 ANNUAL
MEETING OF STOCKHOLDERS |
| |
AGE
|
| |
DIRECTOR SINCE
|
|
Jean-Charles Soria, M.D., Ph.D, has served as a member of our board of directors since October 16, 2020. Dr. Soria is a Professor of Medicine and Medical Oncology at the University of Paris-Saclay and has served as General Director of the Gustave Roussy Cancer Center since December 2019. During his tenure at the Gustave Roussy Cancer Center, Dr. Soria has held a number of positions, including Chairman of the Department of Drug Development from 2013 to 2017, member of the Lung Cancer Division focusing on targeted therapies from 2001 to 2017, Chief of the Gustave Roussy SITEP from 2008 to 2013 and Director of the Gustave Roussy Site for Integrated Research on Cancer Program from 2013 to 2017. From 2017 to 2019, Dr. Soria was Senior Vice President at Medimmune LLC, a fully owned subsidiary of AstraZeneca, where he was responsible for early oncology research and development with specific responsibility for immunotherapy, antibody-drug conjugates and cell therapy. Dr. Soria was also Adjunct Professor of Medicine at the MD Anderson Cancer Center from 2013 to 2017. Our Board of Directors believes that Dr. Soria’s experience in the life sciences industry and drug development experience qualify him to serve on our Board of Directors. | | |
50
|
| |
2020
|
|
Michael A. Kelly has served as a member of our board of directors since February 2019. Mr. Kelly is currently the President of Sentry Hill Partners, LLC, a consulting firm in the global life sciences industry that he founded in 2018. He previously served in various leadership positions at Amgen, Inc., or Amgen, from 2003 to 2017, including Senior Vice President, Global Business Services from 2014 to 2017, Acting Chief Financial Officer in 2010 and 2014 and Vice President, Corporate Planning & Control and Chief Accounting Officer from 2005 to 2010. Prior to joining Amgen, Mr. Kelly previously served as Chief Financial Officer of Tanox, Inc. from 2000 to 2003 and as Vice President, Finance and Corporate Controller of Biogen, Inc. from 1998 to 2000 and Vice President, Finance and Chief Financial Officer of NutraSweet Kelco Company, a division of Monsanto Life Sciences Company from 1996 to 1998. Mr. Kelly received a B.A. from Florida A&M University. Our Board of Directors believes that Mr. Kelly’s experience in the life sciences industry and his financial background qualify him to serve on our Board of Directors. | | |
64
|
| |
2019
|
|
CLASS III DIRECTORS — TERM EXPIRING AT THE 2022 ANNUAL
MEETING OF STOCKHOLDERS |
| |
AGE
|
| |
DIRECTOR SINCE
|
|
Julie O’Neill has served as a member of our board of directors since November 2018. Ms. O’Neill previously served as the Executive Vice President, Global Operations of Alexion Pharmaceuticals, Inc., a position she held from January 2015 to September 2018. From February 2014 to January 2015, Ms. O’Neill was Senior Vice President of Global Manufacturing Operations and General Manager of Alexion Pharma International Trading. Prior to joining Alexion, Ms. O’Neill served in various leadership positions at Gilead Sciences, Inc., or Gilead, from 1997 to 2014 including Vice President of Operations and General Manager of Ireland from 2011 to 2014. Prior to Gilead, Ms. O’Neill held leadership positions at Burnil Pharmacies and Helsinn Birex Pharmaceuticals. She was previously Chairperson for the National Standards Authority of Ireland and is a member of the board and chairs the audit committee of the National Institute for Bioprocessing Research & Training. Ms. O’Neill serves as member of the board of directors of DBV Technologies S.A. (Nasdaq: DBVT) and ICON plc. Ms. O’Neill received a Bachelor of Science in Pharmacy from University of Dublin, Trinity College and a Masters of Business Administration from University College Dublin (Smurfit School of Business) and is a Chartered Director. Our Board of Directors believes that Ms. O’Neill’s experience in the life sciences industry and her knowledge of corporate development matters qualify her to serve on our Board of Directors. | | |
55
|
| |
2018
|
|
Christoph Lengauer, Ph.D., has served as a member of our board of directors since June 2018. Dr. Lengauer has been a partner at Third Rock Ventures since May 2019 and was previously a venture partner from January 2016 to May 2019. Dr. Lengauer has served as founding Chief Innovation Officer at Thrive Early Detection since April 2019. He has been the Chief Scientific Officer of Celsius Therapeutics from April 2018 till April 2020. He has been the Executive Vice President of Blueprint Medicines since November 2016, where he was previously the Chief Scientific Officer and Chief Drug Hunter from January 2012 to November 2016, the Vice President and Global Head of Oncology Drug Discovery and Preclinical Development at Sanofi S.A., a multinational pharmaceutical company, from May 2008 to January 2012 and Executive Director and Senior Unit Head of Oncology Discovery at the Novartis Institutes for Biomedical Research from July 2005 to May 2008. Prior to his experience at Novartis, Dr. Lengauer was a member of the faculty at the Sidney Kimmel Comprehensive Cancer Center at the Johns Hopkins University School of Medicine from 1997 to 2005. Dr. Lengauer received an M.Sc. in human genetics from the University of Salzburg, Austria, a Ph.D. in biology from the University of Heidelberg, Germany and an M.B.A. in medical services management from The Johns Hopkins University. Our Board of Directors believes that Dr. Lengauer’s experience in biopharmaceutical research and development and his experience in venture capital qualify him to serve on our Board of Directors. | | |
56
|
| |
2018
|
|
CLASS III DIRECTORS — TERM EXPIRING AT THE 2022 ANNUAL
MEETING OF STOCKHOLDERS |
| |
AGE
|
| |
DIRECTOR SINCE
|
|
Reinhard Kandera has served as our Chief Financial Officer since April 2017 and as a member of our board of directors since June 2018. Mr. Kandera served as the Chief Financial Officer and Member of the Management Board of Valneva SE, or Valneva, from May 2013 to April 2017. Prior to Valneva, he served as Chief Financial Officer of Intercell AG, or Intercell, from March 2009 to May 2013 and as Member of Intercell’s Management Board from November 2009 to May 2013, which merged with Vivalis SA to become Valneva in May 2013. Mr. Kandera received doctorate degrees in Business Administration and in Law from the Vienna University. Our Board of Directors believes that Mr. Kandera’s experience gained from serving as our Chief Financial Officer, combined with his previous qualifications and the skills and experience he has developed during his extensive career in the life sciences industry, qualify him to serve as a member of our Board of Directors. | | |
51
|
| |
2018
|
|
NON-CONTINUING DIRECTORS | | | | | | | |
Graziano Seghezzi has served as a member of our board of directors since March 2011. Mr. Seghezzi is currently Managing Partner of Sofinnova Partners, which he joined in 2006. Previously, he seed funded and was a member of the board of directors of GlycoVaxyn (Switzerland), which was sold to GlaxoSmithKline in 2015, and Omthera Pharmaceuticals, which went public on Nasdaq in 2013 and was then sold to AstraZeneca later that year. Mr. Seghezzi was a principal at Index Ventures in Geneva, Switzerland from 2003 to 2006, and previously began his career at Sofinnova Partners from 2001 to 2003. Mr. Seghezzi also serves as a member of the board of directors of Inotrem (France), Mission Thereapeutics (United Kingdom), Camphos Therapeutics (United Kingdom), Leucid Bio (United Kingdom), Breath Therapeutics (Germany), Corvidia Therapeudics (USA), Polyneuron, Hookipa Biotech GmbH (Austria), Hotspot Therapeutics (USA), Erydel SpA (Milan), Creabilis Therapeutics (Italy), Crescendo Biologics (United Kingdom) and BiovelocITA (Milan). Mr. Seghezzi holds a degree in genetics and microbiology from the University of Pavia (Italy) and an M.B.A. from the RSM-Erasmus University (Netherlands). Our Board of Directors believes that Mr. Seghezzi’s experience as a venture capital investor in biopharmaceutical companies and his training in both business and biology qualify him to serve as a member of our Board of Directors. Mr. Seghezzi’s decision to not stand for reelection is not the result of any disagreement with the Company relating to any of our operations, policies or practices. | | |
52
|
| |
2011
|
|
Name
|
| |
Age
|
| |
Position(s)
|
|
Joern Aldag(1) | | |
62
|
| | Chief Executive Officer, Director | |
Reinhard Kandera(1) | | |
51
|
| | Chief Financial Officer, Director | |
Igor Matushansky, M.D., Ph.D. | | |
48
|
| | Chief Medical Officer and Global Head of Research and Development | |
Klaus Orlinger, Ph.D. | | |
43
|
| | Executive Vice President, Research | |
Roman Necina, Ph.D. | | |
53
|
| | Chief Technology Officer | |
Christine Baker | | |
56
|
| | Chief Business Officer | |
Name and Principal Position
|
| |
Year
|
| |
Salary ($)
|
| |
Stock
Awards ($)(1) |
| |
Option
Awards ($)(1) |
| |
Non-Equity
Incentive Plan Compensation ($)(2) |
| |
All Other
Compensation ($) |
| |
Total ($)
|
| |||||||||||||||||||||
Joern Aldag(3)
Chief Executive Officer |
| | | | 2020 | | | | | | 495,102 | | | | | | 49,082 | | | | | | 1,081,912 | | | | | | 297,940 | | | | | | — | | | | | | 1,924,036 | | |
| | | 2019 | | | | | | 469,205 | | | | | | | | | | | | 5,617,254 | | | | | | 281,522 | | | | | | — | | | | | | 6,367,981 | | | ||
Reinhard Kandera(3)
Chief Financial Officer |
| | | | 2020 | | | | | | 373,806 | | | | | | 24,208 | | | | | | 418,700 | | | | | | 175,137 | | | | | | 13,132(4) | | | | | | 1,004,983 | | |
| | | 2019 | | | | | | 352,248 | | | | | | | | | | | | 814,250 | | | | | | 169,079 | | | | | | 12,902 | | | | | | 1,348,479 | | | ||
Igor Matushansky
Chief Medical Officer |
| | | | 2020 | | | | | | 399,750 | | | | | | 32,531 | | | | | | 352,703 | | | | | | 189,322 | | | | | | 13,862(5) | | | | | | 988,168 | | |
| | | 2019 | | | | | | 393,538 | | | | | | | | | | | | 483,675 | | | | | | 177,092 | | | | | | 88,409 | | | | | | 1,142,714 | | |
Name
|
| |
Target Bonus
(% of base salary) |
| |||
Joern Aldag
|
| | | | 50 | | |
Reinhard Kandera
|
| | | | 40 | | |
Igor Matushansky
|
| | | | 40 | | |
| | |
Option Awards
|
| |
Stock Awards
|
| ||||||||||||||||||||||||||||||||||||
Name
|
| |
Vesting
Commencement Date |
| |
Number of
Securities Underlying Unexercised Options (#) Exercisable |
| |
Number of
Securities Underlying Unexercised Options (#) Unexercisable(1) |
| |
Option
Exercise Price ($) |
| |
Option
Expiration Date |
| |
Number of
Shares or Units of Stock That Have Not Vested (#)(2) |
| |
Market Value
of Shares or Units of Stock That Have Not Vested ($)(3) |
| |||||||||||||||||||||
Joern Aldag
|
| | | | 6/1/2016 | | | | | | 395,852 | | | | | | — | | | | | | 0.10 | | | | | | 12/31/2026 | | | | | | | | | | | | | | |
| | | 4/17/2019 | | | | | | 226,746 | | | | | | 377,910 | | | | | | 14.00 | | | | | | 4/17/2029 | | | | | | | | | | | | | | | ||
| | | 4/20/2020 | | | | | | 0 | | | | | | 200,000 | | | | | | 8.03 | | | | | | 4/20/2030 | | | | | | | | | | | | | | | ||
| | | 7/20/2020 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 4,128 | | | | | | 45,780 | | | ||
Reinhard Kandera
|
| | | | 6/1/2017 | | | | | | 64,946 | | | | | | 9,278 | | | | | | 0.10 | | | | | | 12/31/2026 | | | | | | | | | | | | | | |
| | | 12/1/2017 | | | | | | 26,267 | | | | | | 8,755 | | | | | | 0.10 | | | | | | 12/31/2026 | | | | | | | | | | | | | | | ||
| | | 4/17/2019 | | | | | | 32,868 | | | | | | 54,780 | | | | | | 14.00 | | | | | | 4/17/2029 | | | | | | | | | | | | | | | ||
| | | 4/20/2020 | | | | | | 0 | | | | | | 77,400 | | | | | | 8.03 | | | | | | 4/20/2030 | | | | | | | | | | | | | | | ||
| | | 7/20/2020 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 2,036 | | | | | | 22,579 | | | ||
Igor Matushansky
|
| | | | 3/1/2017 | | | | | | — | | | | | | 8,079 | | | | | | 0.10 | | | | | | 12/31/2026 | | | | | | | | | | | | | | |
| | | 1/1/2018 | | | | | | — | | | | | | 14,208 | | | | | | 0.10 | | | | | | 12/31/2026 | | | | | | | | | | | | | | | ||
| | | 1/1/2019 | | | | | | — | | | | | | 7,669 | | | | | | 0.10 | | | | | | 12/31/2026 | | | | | | | | | | | | | | | ||
| | | 10/1/2018 | | | | | | 22,122 | | | | | | 22,121 | | | | | | 10.33 | | | | | | 12/31/2026 | | | | | | | | | | | | | | | ||
| | | 4/17/2019 | | | | | | 19,524 | | | | | | 32,540 | | | | | | 14.00 | | | | | | 4/17/2029 | | | | | | | | | | | | | | | ||
| | | 4/20/2020 | | | | | | — | | | | | | 65,200 | | | | | | 8.03 | | | | | | 4/20/2030 | | | | | | | | | | | | | | | ||
| | | 7/20/2020 | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | 2,736 | | | | | | 30,342 | | |
| | |
Column (A)
|
| |
Column (B)
|
| |
Column (C)
|
| |||||||||
Plan Category
|
| |
Number of
Securities to be Issued Upon Exercise of Outstanding Options, Warrants and Rights |
| |
Weighted
Average Exercise Price of Outstanding Options, Warrants and Rights |
| |
Number of
Securities Remaining Available for Future Issuance Under Equity Compensation Plans (Excluding Securities Reflected in Column A) |
| |||||||||
Equity Compensation Plans Approved by Stockholders(1)
|
| | | | 3,555,945 | | | | | | 8.45 | | | | | | 1,169,789 | | |
Equity Compensation Plans Not Approved by Stockholders
|
| | | | 0 | | | | | | 0 | | | | | | 0 | | |
Total(2)
|
| | | | 3,555,945 | | | | | | 8.45 | | | | | | 1,169,789 | | |
Name
|
| |
Fees earned or
paid in cash ($)(1) |
| |
Option awards
($) (2) |
| |
Total
($) |
| |||||||||
Jan van de Winkel(3)
|
| | | | 87,503 | | | | | | 146,088 | | | | | | 233,591 | | |
Christoph Lengauer(4)
|
| | | | 44,005 | | | | | | 73,044 | | | | | | 117,049 | | |
Sander van Deventer(5)
|
| | | | 23,757 | | | | | | — | | | | | | 23,757 | | |
Graziano Seghezzi(6)
|
| | | | 45,008 | | | | | | 73,044 | | | | | | 118,052 | | |
Julie O’Neill(7)
|
| | | | 47,504 | | | | | | 73,044 | | | | | | 120,548 | | |
Michael A. Kelly(8)
|
| | | | 55,088 | | | | | | 73,044 | | | | | | 128,132 | | |
David R. Kaufman(9)
|
| | | | 43,756 | | | | | | 73,044 | | | | | | 116,800 | | |
Jean-Charles Soria(10)
|
| | | | 10,000 | | | | | | 164,033 | | | | | | 174,033 | | |
| | |
Annual Retainer
|
| |||
Board of Directors: | | | | | | | |
All non-employee members
|
| | | $ | 40,000 | | |
Additional retainer for Non-Executive Chairman of the Board
|
| | | $ | 30,000 | | |
Audit Committee: | | | | | | | |
Chairman
|
| | | $ | 22,500 | | |
Non-Chairman members
|
| | | $ | 15,000 | | |
Compensation Committee: | | | | | | | |
Chairman
|
| | | $ | 15,000 | | |
Non-Chairman members
|
| | | $ | 10,000 | | |
Nominating and Corporate Governance Committee: | | | | | | | |
Chairman
|
| | | $ | 11,500 | | |
Non-Chairman members
|
| | | $ | 7,500 | | |
Name and Address of Beneficial Owner(1)
|
| |
Number of
Shares Beneficially Owned |
| |
Percentage of
Shares Beneficially Owned |
| ||||||
5% Stockholders | | | | | | | | | | | | | |
Sofinnova Capital VI FCPR(2)
|
| | | | 3,471,216 | | | | | | 13.35% | | |
Forbion Capital Fund II Coöperatief U.A.(3)
|
| | | | 2,141,887 | | | | | | 8.24% | | |
Entities affiliated with Redmile Group(4)
|
| | | | 2,573,471 | | | | | | 9.99% | | |
Gilead Sciences, Inc.(5)
|
| | | | 2,092,799 | | | | | | 8.05% | | |
Takeda Ventures, Inc.(6)
|
| | | | 1,333,588 | | | | | | 5.13% | | |
Directors and Named Executive Officers | | | | | | | | | | | | | |
Joern Aldag(7)
|
| | | | 761,712 | | | | | | 2.93% | | |
Reinhard Kandera(8)
|
| | | | 166,561 | | | | | | * | | |
Igor Matushansky(9)
|
| | | | 167,612 | | | | | | * | | |
Jan van de Winkel(10)
|
| | | | 95,398 | | | | | | * | | |
Christoph Lengauer(11)
|
| | | | 21,893 | | | | | | * | | |
Jean-Charles Soria
|
| | | | 0 | | | | | | * | | |
Graziano Seghezzi(12)
|
| | | | 22,400 | | | | | | * | | |
Julie O’Neill(13)
|
| | | | 21,893 | | | | | | * | | |
Michael A. Kelly(14)
|
| | | | 12,800 | | | | | | * | | |
David R. Kaufman(15)
|
| | | | 12,800 | | | | | | * | | |
All executive officers and directors as a group (13 persons)(16)
|
| | | | 1,490,831 | | | | | | 5.74 | | |
Fee Category
|
| |
Year ended
December 31, 2020 |
| |
Year ended
December 31, 2019 |
| ||||||
Audit Fees(1)
|
| | | | 497,387 | | | | | | 690,124 | | |
Audit-Related Fees(2)
|
| | | | 821,326 | | | | | | 1,066,515 | | |
All Other Fees
|
| | | | 0 | | | | | | 0 | | |
Total
|
| | | | 1,318,713 | | | | | | 1,756,639 | | |